Transsexual hormone regime

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Background: Although the Endocrine Society Guidelines for gender dysphoria stipulated that cross-sex hormone therapy CHT achieve gonadal steroid levels equivalent to those of a cisperson of the chosen sex, for transgender women male-to-female gender dysphoria , current gonadal therapy is usually estradiol. Accumulated evidence indicates that normally ovulatory menstrual cycles are necessary for ciswomen's current fertility, as well as for later-life bone and cardiovascular health and the prevention of breast and endometrial cancers. Comprehensive progesterone physiology research plus a brief review of transgender women's literature to assess current therapy and clinical outcomes, including morbidity and mortality. Purpose: To emphasize that both ovarian hormones, progesterone as well as estradiol, are theoretically and clinically important for optimal transgender women's CHT. Evidence synthesis: It is important to add progesterone to estradiol and an antiandrogen in transgender women's CHT. Conclusions: Evidence has accrued that normal progesterone and ovulation , as well as physiological estradiol levels, is necessary during ciswomen's premenopausal menstrual cycles for current fertility and long-term health; transgender women deserve progesterone therapy and similar potential physiological benefits.
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How to Start Hormone Replacement Therapy (Male to Female)

Transgender women and transfeminine people are people whose assigned sex at birth is male, yet they exist as women. Transgender people represent a group that includes not just transgender women but also non-binary people who have a more feminine gender identity than the one that is expected for their recorded sex at birth. The term "transfeminine" is an umbrella term that encompasses both transgender women and feminine people of non-binary identity. Many transgender people experience what is known as gender dysphoria —this is discomfort caused by people's bodies not matching their sense of identity. Not every transgender person deals with their gender dysphoria in the same way. However, for many people, hormone therapy can help them feel more like themselves.
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Transgender hormone therapy (female-to-male)

Feminizing hormone therapy is used to induce physical changes in your body caused by female hormones during puberty secondary sex characteristics to promote the matching of your gender identity and your body gender congruence. If feminizing hormone therapy is started before the changes of male puberty begin, male secondary sex characteristics, such as increased body hair and changes in voice pitch, can be avoided. Feminizing hormone therapy is also referred to as cross-sex hormone therapy. During feminizing hormone therapy, you'll be given medication to block the action of the hormone testosterone.
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Last Updated: April 21, References. This article was co-authored by our trained team of editors and researchers who validated it for accuracy and comprehensiveness. There are 22 references cited in this article, which can be found at the bottom of the page.
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